I am a pathology resident at MGH. I am generally interested in understanding how the molecules produced by our cells impact human development, health, and disease. I have a broad set of research interests that include exploring mechanisms of endothelial cell plasticity as a model for vertebrate gene regulation and cell identity, treating diseases of the brain and eye by manipulating gene expression at the blood-brain and blood-retina barriers, anti-phage defense systems in bacteria, and the role of symbiosis in prokaryotic and eukaryotic evolution.
I earned my ScB in Neuroscience at Brown where I worked with Eric Morrow. I pursued combined MD-PhD training in the Medical Scientist Training Program at Johns Hopkins where I completed my doctoral research with Jeremy Nathans. Using next-generation sequencing-based assays, I generated a broad catalogue of gene regulatory features across early postnatal vascular endothelium of the brain, liver, lung, and kidney from the mouse. I then focused on the role of beta-catenin/Wnt signaling in blood-brain barrier development and maintenance. You can explore this data at the Vascular Endothelial Cell Trans-omics Resource Database.
Outside of my academic pursuits, I enjoy watching dark comedies and spending time with my wife and dog.
MD, 2021
Johns Hopkins University School of Medicine
PhD in Neuroscience, 2021
Johns Hopkins University School of Medicine
ScB in Neuroscience, 2012
Brown University