I am a pathology resident at MGH. I am generally interested in understanding how the molecules produced by our cells impact human development, health, and disease. I have a broad set of research interests that include exploring mechanisms of endothelial cell plasticity as a model for vertebrate gene regulation and cell identity, treating diseases of the brain and eye by manipulating gene expression at the blood-brain and blood-retina barriers, anti-phage defense systems in bacteria, and the role of symbiosis in prokaryotic and eukaryotic evolution.

I earned my ScB in Neuroscience at Brown where I worked with Eric Morrow. I pursued combined MD-PhD training in the Medical Scientist Training Program at Johns Hopkins where I completed my doctoral research with Jeremy Nathans. Using next-generation sequencing-based assays, I generated a broad catalogue of gene regulatory features across early postnatal vascular endothelium of the brain, liver, lung, and kidney from the mouse. I then focused on the role of beta-catenin/Wnt signaling in blood-brain barrier development and maintenance. You can explore this data at the Vascular Endothelial Cell Trans-omics Resource Database.

Outside of my academic pursuits, I enjoy watching dark comedies and spending time with my wife and dog.